1 introduction drug resistance is a well known phenomenon that results when diseases become tolerant to pharmaceutical treatments this concept was first considered when bacteria became resistant to certain antibiotics but since then similar mechanisms have been found to occur in other diseases including cancer. Drug resistance in cancer whereby a proportion of cancer cells evades chemotherapy poses a profound and continuing challenge for the effective treatment of cancer the principles underlying the biological mechanisms behind this phenomenon are clearly understood and explained in this volume. While efforts are being made to identify the mechanisms of resistance and to develop novel drugs and therapeutic agents to overcome them the lack of physiologically relevant drug resistant cancer model systems remains a significant challenge drug resistance in cancer comes in two forms intrinsic resistance and acquired resistance. Get this from a library drug resistance in cancer mechanisms and models james h goldie andrew james coldman this volume clearly explains the biological mechanisms behind proportions of cancer cells evading chemotherapy the authors also explain the dynamic forces which shape tumour growth including . Cancer drug resistance is an open access journal focusing on pharmacological aspects of drug resistance and its reversal molecular mechanisms of drug resistance and drug classes etc both clinical and experimental aspects of drug resistance in cancer are included
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